Publications

Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover.

Authors: Brabec T, Schwarzer M, Kováčová K, Dobešová M, Schierová D, Březina J, Pacáková I, Šrůtková D, Ben-Nun O, Goldfarb Y, Šplíchalová I, Kolář M, Abramson J, Filipp D, Dobeš J

J Exp Med 2024; 221 (1): e20230194.

Microbiota modulates the steroid response to acute immune stress in male mice

Authors: Vagnerová K, Gazárková T, Vodička M, Ergang P, Klusoňová P, Hudcovic T, Šrůtková D, Petr Hermanová P, Nováková L, Pácha J.

Front Immunol. 2024 Feb 1;15:1330094

The effect of oral butyrate on colonic short-chain fatty acid transporters and receptors depends on microbial status

Authors: Vagnerová K, Hudcovic T, Vodička M, Ergang P, Klusoňová P, Petr Hermanová P, Šrůtková D, Pácha J

Front Pharmacol. 2024 Mar 26;15:1341333

Polysaccharide BAP1 of Bifidobacterium adolescentis CCDM 368 is a biologically active molecule with immunomodulatory properties.

Authors: Pacyga-Prus K, Jakubczyk D, Sandström C, Šrůtková D, Pyclik M J, Leszczyńska K, Ciekot J, Razim A, Schwarzer M, Górska S

Carbohydrate Polymers 2023

Gut microbiota and Lactobacillus species maintain the small intestine stem cell niche and ameliorate the severity of necrotizing enterocolitis

Authors: Svabova T, Jelinkova A, Gautam UK

Allergy 2023 Nov;78(11):3038-3040

The mechanism of immune dysregulation caused by porcine reproductive and respiratory syndrome virus (PRRSV).

Authors: Sinkora M, Toman M, Stepanova K, Stepanova H, Leva L, Sinkorova J, Moutelikova R, Salat J, Srutkova D, Schwarzer M, Sinkora S, Kupcova Skalnikova H, Nechvatalova K, Hudcovic T, Hermanova P, Pfeiferova S, Kratochvilova M, Kavanova L, Dusankova B, Sinkora M Jr.

Microbes Infect. 2023 Sep-Oct;25(7):105146.

Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid.

Authors: Šimek M, Turková K, Schwarzer M, Nešporová K, Kubala L, Hermannová M, Foglová T, Šafránková B, Šindelář M, Šrůtková D, Chatzigeorgiou S, Novotná T, Hudcovic T, Velebný V

Carbohydrate Polymers 2023

Exopolysaccharide from Lacticaseibacillus rhamnosus induces IgA production in airways and alleviates allergic airway inflammation in mouse model.

Authors: Srutkova D, Kozakova H, Novotna T, Gorska S, Petr Hermanova P, Hudcovic T, Svabova T, Sinkora M, Schwarzer M

Eur J Immunol. 2023 Jul;53(7):e2250135.

Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.

Authors: Schwarzer M, Gautam UK, Makki K, Lambert A, Brabec T, Joly A, Srutkova D, Poinsot P, Novotna T, Geoffroy S, Courtin P, Hermanova PP, Matos RC, Landry JJM, Gerard C, Bulteau AL, Hudcovic T, Kozakova H, Filipp D, Chapot-Chartier MP, Sinkora M, Peretti N, Boneca IG, Chamaillard M, Vidal H, De Vadder F, Leulier F

Science. 2023 Feb 24;379(6634):826-833.

IL-17 driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum.

Authors: Brabec T, Vobořil M, Schierova D, Valter E, Splichalova I, Dobeš J, Brezina J, Dobesova M, Aidarova A, Jakubec M, Manning J, Blumberg R, Waissman A, Kolar M, Kubovciak J, Srutkova D, Hudcovic T, Schwarzer M, Fronkova E, Pinkasova T, Jabandziev P, Filipp D

Mucosal Immunol 2023 Feb 2:S1933-0219(23)00005-3

Gut microbe Lactiplantibacillus plantarum undergoes different evolutionary trajectories between insects and mammals.

Authors: Maritan E, Gallo M, Srutkova D, Jelinkova A, Benada O, Kofronova O, Silva‑Soares N F, Hudcovic T, Gifford I, Barrick J E, Schwarzer M and Martino M E

BMC Biology 20, 290 (2022)

Effect of DSS-Induced Ulcerative Colitis and Butyrate on the Cytochrome P450 2A5: Contribution of the Microbiome

Authors: Satka S, Frybortova V, Zapletalova I, Anzenbacher P, Anzenbacherova E, Kozakova H, Srutkova D, Hudcovic T, Jourova L

Int J Mol Sci. 2022 Oct 1;23(19):11627

The order of immunoglobulin light chain κ and λ usage in primary and secondary lymphoid tissues of germ-free and conventional piglets

Authors: Stepanova K, Sinkorova J, Srutkova D, Sinkora M Jr, Sinkora S, Splichal I, Splichalova A, Butler JE, Sinkora M

Dev Comp Immunol. 2022 Jun;131:104392

Butyrate Treatment of DSS-Induced Ulcerative Colitis Affects the Hepatic Drug Metabolism in Mice

Authors: Jourova L, Satka S, Frybortova V, Zapletalova I, Anzenbacher P, Anzenbacherova E, Hermanova PP, Drabonova B, Srutkova D, Kozakova H, Hudcovic T

Front Pharmacol. 2022 Jul 19;13:936013

Editorial: Probiotic bacteria-derived effector molecules and their impact on the host in health and disease.

Authors: Górska S, Schwarzer M, Schabussova I, Zawilak-Pawlik AM and Sandström C

Frontiers in Microbiology 13:1089461, 2022

Polymeric IgA-associated glycans protect epithelial cells and experimental animals from necrotoxigenic E. coli O55 infection.

Authors: Brokesova D, Raskova Kafkova L, Skarda J, Perutka Z, Sebela M, Zakostelska Z, Reiss Z, Stepanova K, Srutkova D, Vannucci L, Novobilsky A, Dvorak J, Kulich P, Stepankova R, Tlaskalova-Hogenova H, Sinkora M, Mestecky J, Raska M.

Mucosal Immunol. 2021 Mar;14(2):511-522.

Early infection-induced natural antibody response.

Authors: Kubelkova K, Hudcovic T, Kozakova H, Pejchal J, Macela A.

Sci Rep. 2021,1541.

Pre-and Neonatal Imprinting on Immunological Homeostasis and Epithelial Barrier Integrity by Escherichia coli Nissle 1917 prevents Allergic Poly-sensitization in Mice.

Authors: Sarate PJ, Srutkova D, Geissler N, Schwarzer M, Schabussova I, Inic-Kanada A, Kozakova H, Wiedermann U

Front. Immunol.

Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions

Authors: Čaja F, Stakheev D, Chernyavskiy O, Křížan J, Dvořák J, Rossmann P, Štěpánková R, Makovický Petr, Makovický Pavol, Kozáková H, Vannucci L.

J Immunotoxicol. 2021, 37.

The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine.

Authors: Ergang P, Vagnerová K, Hermanová P, Vodička M, Jágr M, Šrůtková D, Dvořáček V, Hudcovic T, Pácha J.

Int J Mol Sci. 2021, 4229.

Phenotypic and clonal stability of antigen-inexperienced memory-like T cells across the genetic background, hygienic status, and aging.

Authors: Moudra A, Niederlova V, Novotny J, Schmiedova L, Kubovciak J, Matejkova T, Drobek A, Pribikova M, Stopkova R, Cizkova D, Neuwirth A, Michalik J, Krizova K, Hudcovic T, Kolar M, Kozakova H, Kreisinger J, Stopka P, Stepanek O.

J Immunol. 2021, 2109.

Viability Status-Dependent Effect of Bifidobacterium longum ssp. longum CCM 7952 on Prevention of Allergic Inflammation in Mouse Model.

Authors: Pyclik MJ, Srutkova D, Razim A, Hermanova P, Svabova T, Pacyga K, Schwarzer M, Górska S.

Front Immunol. 2021, 707728.

Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets

Authors: Raskova Kafkova L, Brokesova D, Krupka M, Stehlikova Z, Dvorak J, Coufal S, Fajstova A, Srutkova D, Stepanova K, Hermanova P, Stepankova R, Uberall I, Skarda J, Novak Z, Vannucci L, Tlaskalova-Hogenova H, Jiraskova Zakostelska Z, Sinkora M, Mestecky J, Raska M.

Mucosal Immunol. 2021, 511.

A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes.

Authors: Darnaud M, De Vadder F, Bogeat P, Boucinha L, Bulteau AL, Bunescu A, Couturier C, Delgado A, Dugua H, Elie C, Mathieu A, Novotná T, Ouattara DA, Planel S, Saliou A, Šrůtková D, Yansouni J, Stecher B, Schwarzer M, Leulier F, Tamellini A.

Nat Commun. 2021, 6686.

Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression.

Authors: Zemanová N, Lněničková K, Vavrečková M, Anzenbacherová E, Anzenbacher P, Zapletalová I, Hermanová P, Hudcovic T, Kozáková H, Jourová L.

PLoS One. 2021,16(11)

Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?

Authors: Castan L, Bøgh KL, Maryniak NZ, Epstein MM, Kazemi S, O'Mahony L, Bodinier M, Smit J, van Bilsen J, Blanchard C, Głogowski R, Kozáková H, Schwarzer M, Noti M, de Wit N, Bouchaud G, Bastiaan-Net S

Allergy 2020, 289-301

Reproducible Colonization of Germ-Free Mice With the Oligo-Mouse-Microbiota in Different Animal Facilities.

Authors: Eberl C, Ring D, Münch PC, Beutler M, Basic M, Slack EC, Schwarzer M, Srutkova D, Lange A, Frick JS, Bleich A, Stecher B

Front Microbiol. 2020, 2999

Probiotic from human breast milk, Lactobacillus fermentum, promotes growth in animal model of chronic malnutrition.

Authors: Poinsot P, Penhoat A, Mitchell M, Sauvinet V, Meiller L, Louche-Pélissier C, Meugnier E, Ruiz M, Schwarzer M, Michalski MC, Leulier F, Peretti N

Pediatr Res. 2020, 374-381

Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins - Their chemical structure and biological attributes.

Authors: Pyclik M, Šrůtková D, Schwarzer M, Górska S.

Int J Biol Macromol. 2020, 333-349

The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice.

Authors: Zemanová N, Anzenbacher P, Zapletalová I, Jourová L, Hermanová P, Hudcovic T, Kozáková H, Vodička M, Pácha J, Anzenbacherová E

Sci Rep. 2020, 8529.

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy.

Authors: Klufa J, Bauer T, Hanson B, Herbold C, Starkl P, Lichtenberger B, Srutkova D, Schulz D, Vujic I, Mohr T, Rappersberger K, Bodenmiller B, Kozakova H, Knapp S, Loy A, Sibilia M

Sci Transl Med 2019, 11

Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?

Authors: Castan L, Bøgh KL, Maryniak NZ, Epstein MM, Kazemi S, O'Mahony L, Bodinier M, Smit JJ, van Bilsen JHM, Blanchard C, Głogowski R, Kozáková H, Schwarzer M, Noti M, de Wit N, Bouchaud G, Bastiaan-Net S.

Allergy 2019, 12.

Crucial Role of Microbiota in Experimental Psoriasis Revealed by a Gnotobiotic Mouse Model.

Authors: Stehlikova Z, Kostovcikova K, Kverka M, Rossmann P, Dvorak J, Novosadova I, Kostovcik M, Coufal S, Srutkova D, Prochazkova P, Hudcovic T, Kozakova H, Stepankova R, Rob F, Juzlova K, Hercogova J, Tlaskalova-Hogenova H, Jiraskova Zakostelska Z

Front Microbiol 2019, 10

Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy.

Authors: Schwarzer M, Hermanova P, Srutkova D, Golias J, Hudcovic T, Zwicker C, Sinkora, M, Akgün J, Wiedermann U, Tuckova L, Kozakova H, Schabussova I

Front Immunol 2019, 10

Gut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome.

Authors: Jourova L, Anzenbacher P, Matuskova Z, Vecera R, Strojil J, Kolar M, Nobilis M, Hermanova P, Hudcovic T, Kozakova H, Kverka M, Anzenbacherova E

Xenobiotica 2019, 49

Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins - their chemical structure and biological attributes.

Authors: Pyclik M, Srutkova D, Schwarzer M, Górska S

Int J Biol Macromol 2019, 147

Interactions Between Gut Microbiota and Acute Restraint Stress in Peripheral Structures of the Hypothalamic-Pituitary-Adrenal Axis and the Intestine of Male Mice

Authors: Vagnerová K, Vodička M, Hermanová P, Ergang P, Šrůtková D, Klusoňová P, Balounová K, Hudcovic T, Pácha J

Front Immunol 2019, 10

Nutritional Mutualism by Promoting the Fitness of Its Intestinal Symbiont Lactobacillus plantarum

Authors: Storelli G, Strigini M, Grenier T, Bozonnet L, Schwarzer M, Daniel C, Matos R, Leulier F

Cell Metab 2018, 27

Gut Microbiota and Host Juvenile Growth

Authors: Schwarzer M, Strigini M, Leulier F

Calcif Tissue Int 2018, 102

Cellular differentiation of non-transformed intestinal epithelial cells is regulated by Lactobacillus rhamnosus and L. casei strains

Authors: Kolinska J, Zakostelecka M, Zemanova Z, Lisa V, Golias J, Kozakova H, Dvorak B

Physiol Res 2018, 67

Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice

Authors: Funda DP, Goliáš J, Hudcovic T, Kozáková H, Špíšek R, Palová-Jelínková L

Front Immunol 2018, 16

Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress

Authors: Vodička M, Ergang P, Hrnčíř T, Mikulecká A, Kvapilová P, Vagnerová K, Šestáková B, Fajstová A, Hermanová P, Hudcovic T, Kozáková H, Pácha J

Brain Behav Immun 2018, 73

Prophylactic and therapeutic inhibition of allergic airway inflammation by probiotic E. coli O83

Authors: Zwicker C, Sarate P, Drinic M, Ambroz K, Korb E, Smole U, Köhler C, Wilson MS, Kozakova H, Sebo P, Kverka M, Wiedermann U, Schabussova I

J Allergy Clin Immunol 2018, 142

Gut microbiota: puppeteer of the host juvenile growth

Authors: Schwarzer M

Curr Opin Clin Nutr Metab Care 2018, 21

The emerging connections between IGF1, the intestinal microbiome, Lactobacillus strains and bone growth

Authors: Poinsot P, Schwarzer M, Peretti N, Leulier

J Mol Endocrinol 2018, 61

Diet Matters: Endotoxin in the Diet Impacts the Level of Allergic Sensitization in Germ-Free Mice

Authors: Schwarzer M, Srutkova D, Hermanova P, Leulier F, Kozakova H, Schabussova I

Plos One 2017, 12

D-Alanylation of teichoic acids contributes to Lactobacillus plantarum-mediated Drosophila growth during chronic undernutrition

Authors: Matos RC, Schwarzer M, Gervais H, Courtin P, Joncour P, Gillet B, Ma D, Bulteau AL, Martino ME, Hughes S, Chapot-Chartier MP, Leulier F

Nature Microbiol 2017, 2

Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health

Authors: Leulier F, MacNeil LT, Lee WJ, Rawls JF, Cani PD, Schwarzer M, Zhao LP, Simpson SJ

Cell Metab 2017, 25

Colonization by nonpathogenic bacteria alters mRNA expression of cytochromes P450 in originally germ-free mice

Authors: Jourová L, Anzenbacher P, Lišková B, Matušková Z, Hermanová P, Hudcovic T, Kozáková H, Hrnčířová L, Anzenbacherová E

Folia Microbiol 2017, 62

Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

Authors: Schwarzer M, Makki K, Storelli G, Machuca-Gayet I, Srutkova D, Hermanova P, Martino ME, Balmand S, Hudcovic T, Heddi A, Rieusset J, Kozakova H, Vidal H, Leulier F.

Science 2016, 351

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

Authors: Kozakova H, Schwarzer M, Tuckova L, Srutkova D, Czarnowska E, Rosiak I, Hudcovic T, Schabussova I, Hermanova P, Zakostelska Z, Aleksandrzak-Piekarczyk T, Koryszewska-Baginska A, Tlaskalova-Hogenova H, Cukrowska B

Cell Mol Immunol 2016, 13

Real-time polymerase chain reaction as a tool for evaluation of magnetic poly(glycidyl methacrylate)-based microspheres in molecular diagnostics

Authors: Trachtová Š, Španová A, Horák D, Kozáková H, Rittich B

Curr Pharm Des 2016, 22

Gnotobiotic mouse model's contribution to understanding host-pathogen interactions

Authors: Kubelková K, Benuchová M, Kozáková H, Šinkora M, Krocová Z, Pejchal J, Macela A

Cell Mol Life Sci 2016, 73

Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner

Authors: Srutkova D, Schwarzer M, Hudcovic T, Zakostelska Z, Drab V, Spanova A, Rittich B, Kozakova H, Schabussova I

Plos One 2015, 10

Genomic and Functional Characterization of the Unusual pLOCK 0919 Plasmid Harboring the spaCBA Pili Cluster in Lactobacillus casei LOCK 0919

Authors: Aleksandrzak-Piekarczyk T, Koryszewska-Bagińska A, Grynberga M, Nowak A, Cukrowska B, Kozakova H, Bardowski J.

Genome Biol Evol 2015, 8

Development of gut inflammation in mice colonized with mucosa-associated bacteria from patients with ulcerative colitis

Authors: Du Z, Hudcovic T, Mrazek J, Kozakova H, Srutkova D, Schwarzer M, Tlaskalova-Hogenova H, Kostovcik M, Kverka M

Gut Pathog 2015, 7

Faecalibacterium prausnitzii strain HTF-F and its extracellular polymeric matrix attenuate clinical parameters in DSS-induced colitis

Authors: Rossi O, Tanweer Khan M, Schwarzer M, Hudcovic T, Šrůtková D, Duncan SH, Stolte EH, Kozáková H, Flint HJ, Samsom JN, Hermie JM, Harmsen HJM., Wells JM

PLoS One 2015, 10

Distinct Immunomodulation of Bone Marrow-Derived Dendritic Cell Responses to Lactobacillus plantarum WCFS1 by Two Different Polysaccharides Isolated from Lactobacillus rhamnosus LOCK 0900

Authors: Gorska S, Schwarzer M, Jachymek W, Srutkova D, Brzozowska E, Kozakova H, Gamian A

Appl Environ Microbiol 2014, 80

Neonatal colonization of germ-free mice with Bifidobacterium longum prevents allergic sensitization to major birch pollen allergen Bet v 1

Authors: Schwarzer M, Srutkova D, Schabussova I, Hudcovic T, Akgun J, Wiedermann U, Kozakova H

Vaccine 2013, 31

Compartment- and malignance-dependent up-regulation of γ-glutamyltranspeptidase and dipeptidyl- peptidase-IV activity in human brain gliomas

Authors: Mareš V, Stremeňová J, Lisá V, Kozáková H, Marek J, Syrůček M, Šoula O, Šedo A

Histol Histopathol 2012, 27

Neonatal colonization of mice with Lactobacillus plantarum producing the aeroallergen Bet v 1 biases towards Th1 and T-regulatory responses upon systemic sensitization

Authors: Schwarzer M, Repa A, Daniel C, Schabussova I, Hrncir T, Pot B, Stepankova R, Hudcovic T

Allergy 2011, 66

Gut microbiota (commensal bacteria) and mucosal barrier in pathogenesis of inflammatory, autoimmune diseases and cancer: Contribution of germ-free and gnotobiotic models of human diseases

Authors: Tlaskalová-Hogenová H, Štěpánková R, Kozáková H, Hudcovic T, Vannucci L, Tučková L, Rossmann P, Hrnčíř T, Kverka M, Zákostelská Z, Klimešová K, Přibylová P, Drastich P, Funda DP

Cell Mol Immunol 2011, 8

Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice

Authors: Hrncir T, Stepankova R, Kozakova H, Hudcovic T, Tlaskalova-Hogenova H

BMC Immunology 2008, 9

Segmented filamentous bacteria in defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RB (high) CD4+ T cell

Authors: Stepankova R, Powrie F, Kofronova O, Kozakova H, Hudcovic T, Hrncir T, Uhlig H, Read S, Rehakova Z, Benada O, Heczko P, Strus M, Bland P, Tlaskalova-Hogenova H

Inflamm Bowel Dis 2007, 13