Introduction

Group leader: Tomáš Hrnčíř, MD., PhD. (hrncir@biomed.cas.cz)

We believe that the increasing incidence of many immune-mediated and metabolic disorders is caused by the compositional and functional alterations of gut microbiota. These alterations - often called dysbiosis - are driven predominantly by lifestyle and dietary changes and may trigger abnormal gene expression and thereby dysregulate the host immune system and metabolism.