Introduction

Group leader: Tomáš Hrnčíř, MD., PhD. (hrncir@biomed.cas.cz)

The global rise in immune-mediated and metabolic disorders, such as multiple sclerosis and metabolic dysfunction–associated steatotic liver disease (MASLD), is increasingly being linked to disruptions in the gut microbiota — our body’s complex microbial ecosystem. These changes, known as dysbiosis, are primarily driven by modern lifestyles, particularly the consumption of processed foods rich in additives and simple sugars, as well as antibiotic use. Such factors alter microbial composition, triggering abnormal gene expression and chronic inflammation, which fuel disease pathogenesis.

Led by Dr. Tomas Hrncir (Google Scholar) (https://scholar.google.com/citations?user=IAmDjGkAAAAJ&hl=en), our group pioneers research using advanced gnotobiotic models to unravel the mechanisms. Our findings highlight how processed foods play a pivotal role in gut microbiota disruption, significantly contributing to disease risk. Contact us to explore collaboration opportunities.