Publications

Dysregulace imunitního systému selat po infekci virem PRRS – nový pohled na možnosti profylaxe této infekce, Dysregulation of the piglet immune system after virus infection PRRS – a new perspective on the possibilities of prophylaxis of this infection.

Authors: Toman M, Nechvatalova K, Stepanova K, Sinkora M.

Veterinářství 2024;74(2):98-101.

Polymeric IgA with unique glycans protects from necrotoxigenic E. coli O55 infection in an animal model

Authors: Brokesova D, Raskova Kafkova L, Skarda J, Perutka Z, Sebela M, Krupka M, Zakostelska Z, Reiss Z, Stepanova K, Srutkova D, Vannucci L, Novobilsky A, Dvorak J, Kulich P, Stepankova R, Tlaskalova-Hogenova H, Sinkora M, Mestecky J, Raska M.

24 January 2024, PREPRINT (Version 1) available at Research Square

Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains.

Authors: Stepanova K, Toman M, Sinkorova J, Sinkora S, Pfeiferova S, Kupcova Skalnikova H, Abuhajiar S, Moutelikova R, Salat J, Stepanova H, Nechvatalova K, Leva L, Hermanova P, Kratochvilova M, DusankovaB, Sinkora M Jr., Horak V, Hudcovic T, Butler JE, Sinkora M

Front Immunol. 2024 Jan 12;14:1292381.

Interleukin-17 Producing Cells in Swine Induced by Microbiota during the Early Postnatal Period - A Brief Research Report.

Authors: Stepanova H, Scheirichova M, Matiasovic J, Hlavova K, Sinkora M, Stepanova K, Faldyna M

Front Immunol. 2023 Sep 20;14:1214444

Exopolysaccharide from Lacticaseibacillus rhamnosus induces IgA production in airways and alleviates allergic airway inflammation in mouse model.

Authors: Srutkova D., Kozakova H, Novotna T, Gorska S, Petr Hermanova P, Hudcovic T, Svabova T, Sinkora M, Schwarzer M.

Eur J Immunol. 2023 Jul;53(7):e2250135.

The mechanism of immune dysregulation caused by porcine reproductive and respiratory syndrome virus (PRRSV).

Authors: Sinkora M, Toman M, Stepanova K, Stepanova H, Leva L, Sinkorova J, Moutelikova R, Salat J, Srutkova D, Schwarzer M, Sinkora S, Kupcova Skalnikova H, Nechvatalova K, Hudcovic T, Hermanova P, Pfeiferova S, Kratochvilova M, Kavanova L, Dusankova B, Sinkora M Jr.

Microbes Infect. 2023 Sep-Oct;25(7):105146.

Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.

Authors: Schwarzer M, Gautam UK, Makki K, Lambert A, Brabec T, Joly A, Srutkova D, Poinsot P, Novotna T, Geoffroy S, Courtin P, Hermanova PP, Matos RC, Landry JJM, Gerard C, Bulteau AL, Hudcovic T, Kozakova H, Filipp D, Chapot-Chartier MP, Sinkora M, Peretti N, Boneca IG, Chamaillard M, Vidal H, De Vadder F, Leulier F.

Science. 2023 Feb 24;379(6634):826-833.

Release of HMGB1 and Toll-like receptors 2, 4, and 9 signaling are modulated by Bifidobacterium animalis subsp. lactis BB-12 and Salmonella Typhimurium in a gnotobiotic piglet model of preterm infants.

Authors: Splichal I., Donovan S.M., Kindlova Z, Stranak Z, Neuzil Bunesova V, Sinkora M, Polakova K, Valaskova B, Splichalova I.

Int J Mol Sci. 2023 Jan 24;24(3):2329.

The order of immunoglobulin light chain κ and λ usage in primary and secondary lymphoid tissues of germ-free and conventional piglets

Authors: Stepanova K, Sinkorova J, Srutkova D, Sinkora M jr., Sinkora S, Splichal I, Splichalova A, Butler JE, Sinkora M

Dev Comp Immunol 2022, 131: 104392.

Consequences of the different order of immunoglobulin gene rearrangements in swine

Authors: Sinkora M, Stepanova K, Sinkorova J

Dev Comp Immunol 2022, 126: 104196.

Comparative aspects of immunoglobulin gene rearrangement arrays in different species

Authors: Sinkora M, Stepanova K, Butler JE, Sinkora M jr., Sinkora S, Sinkorova J

Front Immunol 2022, 13, 823145.

Immunoglobulin light chain κ precedes λ rearrangement in swine but a majority of λ⁺ B cells are generated earlier

Authors: Sinkora M, Stepanova K, Sinkorova J

Dev Comp Immunol 2020, 111: 103751.

Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets

Authors: Raskova Kafkova L, Brokesova D, Krupka M, Stehlikova Z, Dvorak J, Coufal S, Fajstova A, Srutkova D, Stepanova K, Hermanova P, Stepankova R, Uberal I, Skarda J, Novak Z, Vannucci L, Tlaskalova Hogenova H, Jiraskova Zakostelska Z, Sinkora M, Mestecky J, Raska M

Mucosal Immunol 2020, Sep 24.

In vivo biodosimetry of porcine T-lymphocyte subsets and NK cells

Authors: Andrejsova L, Sinkorova Z, Sinkora J, Tichy A, Filipova A, Nemcova M, Sinkora M

Radiat Prot Dosimetry 2020, 186: 181-185.

High mobility group Box 1 and TLR4 signaling pathway in gnotobiotic piglets colonized/infected with L. amylovorus, L. mucosae, E. coli Nissle 1917 and S. Typhimurium

Authors: Splichal I, Donovan SM, Jenistova V, Splichalova I., Salmonova H, Vlkova E, Bunesova VN, Sinkora M, Killer J, Skrivanova E, Splichalova A

Int J Mol Sci 2019, 20(24): 6294.

Impact of the lipopolysaccharide chemotype of Salmonella enterica serovar Typhimurium on virulence in gnotobiotic piglets

Authors: Splichalova A, Splichalova Z, Karasova D, Rychlik I, Trevisi P, Sinkora M, Splichal I

Toxins 2019, 11: 9

T cells in swine completely rearrange immunoglobulin heavy chain genes

Authors: Sinkorova J, Stepanova K, Butler JE, Sinkora M

Dev Comp Immunol 2019, 99: 103396

Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy.

Authors: Schwarzer M, Hermanova P, Srutkova D, Golias J, Hudcovic T, Zwicker C, Sinkora M, Akgün J, Wiedermann U, Tuckova L, Kozakova H, Schabussova I

Front Immunol. 2019;10:205.

Perturbation of thymocyte development underlies the PRRS pandemic: A testable hypothesis.

Authors: Butler JE, Sinkora M, Wang G, Stepanova K, Li Y, Cai X

Front Immunol. 2019, 10:1077.

The role of αβ T-cells in spontaneous regression of melanoma tumors in swine.

Authors: Cizkova J, Sinkorova Z, Strnadova K, Cervinkova M, Horak V, Sinkora J, Stepanova K, Sinkora M.

Dev Comp Immunol. 2019, 92: 60-68.

Antibody Repertoire Development in Swine.

Authors: Butler JE, Wertz N, Sinkora M.

Annu Rev Anim Biosci. 2017, 5: 255-279.

Ig Light Chain Precedes Heavy Chain Gene Rearrangement during Development of B Cells in Swine.

Authors: Sinkora M, Sinkorova J, Stepanova K.

J Immunol. 2017, 198: 1543-1552.

Gnotobiotic mouse model's contribution to understanding host-pathogen interactions.

Authors: Kubelkova K, Benuchova M, Kozakova H, Sinkora M, Krocova Z, Pejchal J, Macela A.

Cell Mol Life Sci. 2016, 73: 3961-3969.

Antibody repertoire development in fetal and neonatal piglets. XXIV. Hypothesis: The ileal Peyer patches (IPP) are the major source of primary, undiversified IgA antibodies in newborn piglets.

Authors: Butler JE, Santiago-Mateo K, Wertz N, Sun X, Sinkora M, Francis DL.

Dev Comp Immunol. 2016, 65: 340-351.

Progress in the use of swine in developmental immunology of B and T lymphocytes.

Authors: Sinkora M, Butler JE.

Dev Comp Immunol. 2016, 58: 1-17.

The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets.

Authors: Potockova H, Sinkorova J, Karova K, Sinkora M.

Dev Comp Immunol. 2015, 51: 99-107.

B cell lymphogenesis in swine is located in the bone marrow.

Authors: Sinkora M, Sinkorova J.

J Immunol. 2014, 193: 5023-5032.

The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2.

Authors: Sinkora M, Butler JE, Lager KM, Potockova H, Sinkorova J.

Vet Res. 2014, 45:91.

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic.

Authors: Butler JE, Lager KM, Golde W, Faaberg KS, Sinkora M, Loving C, Zhang YI.

Immunol Res. 2014, 59: 81-108.

The enigma of the lower gut-associated lymphoid tissue (GALT).

Authors: Butler JE, Sinkora M.

J Leukoc Biol. 2013, 94: 259-270.

Porcine γδ T lymphocytes can be categorized into two functionally and developmentally distinct subsets according to expression of CD2 and level of TCR.

Authors: Stepanova K, Sinkora M.

J Immunol. 2013, 190: 2111-2120.

Different anti-CD21 antibodies can be used to discriminate developmentally and functionally different subsets of B lymphocytes in circulation of pigs.

Authors: Sinkora M, Stepanova K, Sinkorova J.

Dev Comp Immunol. 2013, 39: 409-418.

Antibody repertoire development in fetal and neonatal piglets. XXII. λ Rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine.

Authors: Sun X, Wertz N, Lager K, Sinkora M, Stepanova K, Tobin G, Butler JE.

Immunology. 2012, 137: 149-159.

The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs.

Authors: Stepanova K, Sinkora M.

Dev Comp Immunol. 2012, 36: 728-740.

An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis.

Authors: Abu-El-Haija M, Sinkora M, Meyerholz DK, Welsh MJ, McCray PB Jr, Butler J, Uc A.

Pancreatology. 2011, 11: 506-515.

Antibody repertoire development in fetal and neonatal piglets. XX. B cell lymphogenesis is absent in the ileal Peyer's patches, their repertoire development is antigen dependent, and they are not required for B cell maintenance.

Authors: Butler JE, Santiago-Mateo K, Sun XZ, Wertz N, Sinkora M, Francis DH.

J Immunol. 2011, 187: 5141-5149.

Ileal Peyer's patches are not necessary for systemic B cell development and maintenance and do not contribute significantly to the overall B cell pool in swine.

Authors: Sinkora M, Stepanova K, Butler JE, Francis D, Santiago-Mateo K, Potockova H, Karova K, Sinkorova J.

J Immunol. 2011, 187: 5150-5161.

Distribution and development of the postnatal murine Vδ1 T-cell receptor repertoire.

Authors: Holtmeier W, Gille J, Zeuzem S, Sinkora M.

Immunology. 2010, 131: 192-201.

The piglet as a model for B cell and immune system development.

Authors: Butler JE, Lager KM, Splichal I, Francis D, Kacskovics I, Sinkora M, Wertz N, Sun J, Zhao Y, Brown WR, DeWald R, Dierks S, Muyldermans S, Lunney JK, McCray PB, Rogers CS, Welsh MJ, Navarro P, Klobasa F, Habe F, Ramsoondar J.

Vet Immunol Immunopathol. 2009, 128: 147-170.

Immunoglobulins, antibody repertoire and B cell development.

Authors: Butler JE, Zhao Y, Sinkora M, Wertz N, Kacskovics I.

Dev Comp Immunol. 2009, 33: 321-333.

The ontogeny of the porcine immune system.

Authors: Sinkora M, Butler JE.

Dev Comp Immunol. 2009, 33: 273-283.

Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment.

Authors: Kolinska J, Lisa V, Clark JA, Kozakova H, Zakostelecka M, Khailova L, Sinkora M, Kitanovicova A, Dvorak B.

J Interferon Cytokine Res. 2008, 28: 287-296.

The isolator piglet: a model for studying the development of adaptive immunity.

Authors: Butler JE, Sinkora M.

Immunol Res. 2007, 39: 33-51.

Antibody repertoire development in fetal and neonatal piglets: XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndrome.

Authors: Butler JE, Lemke CD, Weber P, Sinkora M, Lager KM.

J Immunol. 2007, 178: 6320-6331.

Two groups of porcine TCRγδ+ thymocytes behave and diverge differently.

Authors: Sinkora M, Sinkorova J, Cimburek Z, Holtmeier W.

J Immunol. 2007, 178: 711-719.

Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology.

Authors: Butler JE, Sinkora M, Wertz N, Holtmeier W, Lemke CD.

Vet Res. 2006, 37: 417-441.

Antibody repertoire development in swine.

Authors: Butler JE, Sun J, Wertz N, Sinkora M.

Dev Comp Immunol. 2006, 30: 199-221.

Lymphocyte development in fetal piglets: facts and surprises.

Authors: Sinkora M, Butler JE, Holtmeier W, Sinkorova J.

Vet Immunol Immunopathol. 2005, 108(1-2): 177-184.

Development of γδ thymocyte subsets during prenatal and postnatal ontogeny.

Authors: Sinkora M, Sinkorova J, Holtmeier W.

Immunology. 2005, 115: 544-555.

Prenatal development of the porcine TCR delta repertoire: dominant expression of an invariant T cell receptor Vdelta3-Jdelta3 chain.

Authors: Holtmeier W, Geisel W, Bernert K, Butler JE, Sinkora M, Rehakova Z, Sinkora J, Caspary WF.

Antibody repertoire development in fetal and neonatal piglets. VI. B cell lymphogenesis occurs at multiple sites with differences in the frequency of in-frame rearrangements.

Authors: Sinkora M, Sun J, Sinkorova J, Christenson RK, Ford SP, Butler JE.

J Immunol. 2003, 170: 1781-1788.

Antibody repertoire development in fetal and neonatal piglets. VIII. Colonization is required for newborn piglets to make serum antibodies to T-dependent and type 2 T-independent antigens.

Authors: Butler JE, Weber P, Sinkora M, Baker D, Schoenherr A, Mayer B, Francis D.

J Immunol. 2002, 169: 6822-6830.

B cell development and VDJ rearrangement in the fetal pig.

Authors: Sinkora M, Sinkorova J, Butler JE.

Vet Immunol Immunopathol. 2002, 87: 341-346.

Early development of immune system in pigs.

Authors: Sinkora J, Rehakova Z, Sinkora M, Cukrowska B, Tlaskalova-Hogenova H.

Vet Immunol Immunopathol. 2002, 87: 301-306.

Monoclonal antibodies putatively recognising activation and differentiation antigens.

Authors: Sinkora J, Rehakova Z, Haverson K, Sinkora M, Dominguez J, Huang CA.

Vet Immunol Immunopathol. 2001, 80: 143-164.

Overview of the Third International Workshop on Swine Leukocyte Differentiation Antigens.

Authors: Haverson K, Saalmüller A, Alvarez B, Alonso F, Bailey M, Bianchi AT, Boersma WJ, Chen Z, Davis WC, Dominguez J, Engelhardt H, Ezquerra A, Grosmaire LS, Hamilton MJ, Hollemweguer E, Huang CA, Khanna KV, Kuebart G, Lackovic G, Ledbetter JA, Lee R, Llanes D, Lunney JK, McCullough KC, Molitor T, Nielsen J, Niewold TA, Pescovitz MD, de la Lastra JM, Rehakova Z, Salmon H, Schnitzlein WM, Seebach J, Simon A, Sinkora J, Sinkora M, Stokes CR, Summerfield A, Sver L, Thacker E, Valpotic I, Yang H, Zuckermann FA, Zwart R.

Vet Immunol Immunopathol. 2001, 80: 5-23.

Antibody repertoire development in fetal and neonatal piglets. V. VDJ gene chimeras resembling gene conversion products are generated at high frequency by PCR in vitro.

Authors: Sinkora M, Sun J, Butler JE.

Mol Immunol. 2000, 37: 1025-1034.

Humoral and cellular immune responses in gluten-treated suckling or hand-fed rats.

Authors: Kozakova H, Stepankova R, Tuckova L, Sinkora M, Jelinkova L, Tlaskalova-Hogenova H.

Physiol Res. 2000, 49: 665-672.

Antibody repertoire development in fetal and neonatal piglets. II. Characterization of heavy chain complementarity-determining region 3 diversity in the developing fetus.

Authors: Butler JE, Weber P, Sinkora M, Sun J, Ford SJ, Christenson RK.

J Immunol. 2000, 165: 6999-7010.

Early ontogeny of thymocytes in pigs: sequential colonization of the thymus by T cell progenitors.

Authors: Sinkora M, Sinkora J, Rehakova Z, Butler JE.

J Immunol. 2000, 165: 1832-1839.

Early ontogeny of monocytes and macrophages in the pig.

Authors: Rehakova Z, Trebichavsky I, Sinkora J, Splíchal I, Sinkora M.

Physiol Res. 1998, 47: 357-363.

Prenatal ontogeny of lymphocyte subpopulations in pigs.

Authors: Sinkora M, Sinkora J, Rehakova Z, Splichal I, Yang H, Parkhouse RM, Trebichavsky I.

Immunology. 1998, 95: 595-603.

Absence of porcine interferon alpha secreting cells in severe combined immunodeficiency (SCID) mice inoculated with porcine leukocytes.

Authors: Splichal I, Sinkora J, Rehakova Z, Sinkora M, Charley B.

Vet Res. 1998, 29: 567-572.

Expression of CD2 on porcine B lymphocytes.

Authors: Sinkora J, Rehakova Z, Sinkora M, Cukrowska B, Tlaskalová-Hogenová H, Bianchi AT, De Geus B.

Immunology. 1998, 95: 443-449.

Effect of controlled antigenic stimulation on lymphocyte subsets in pigs and pig fetuses.

Authors: Rehakova Z, Sinkora J, Sinkora M, Kozakova H, Splíchal I, Barot-Ciorbaru R, Trebichavský I.

Folia Microbiol (Praha). 1998, 43: 513-516.

Monoclonal antibodies putatively identifying porcine B cells.

Authors: Denham S, Zwart RJ, Whittall JT, Pampusch M, Corteyn AH, Bianchi AT, Murtaugh MP, Parkhouse RM, Tlaskalova H, Sinkora J, Sinkora M, Rehakova Z.

Vet Immunol Immunopathol. 1998, 60: 317-328.

Cellular expression of the cytolytic factor in earthworms Eisenia foetida.

Authors: Bilej M, Rossmann P, Sinkora M, Hanusova R, Beschin A, Raes G, De Baetselier P.

Immunol Lett. 1998, 60: 23-29.

In vivo study of interferon-alpha-secreting cells in pig foetal lymphohaematopoietic organs following in utero TGEV coronavirus injection.

Authors: Splichal I, Rehaková Z, Sinkora M, Sinkora J, Trebichavský I, Laude H, Charley B.

Res Immunol. 1997, 148: 247-256.

Early ontogeny of immune cells and their functions in the fetal pig.

Authors: Trebichavsky I, Tlaskalova H, Cukrowska B, Splichal I, Sinkora J, Rehakova Z, Sinkora M, Pospisil R, Kovaru F, Charley B, Binns R, White A.

Vet Immunol Immunopathol. 1996, 54: 75-81.

Isotype and antibody specificity of spontaneously formed immunoglobulins in pig fetuses and germ-free piglets: production by CD5— B cells.

Authors: Cukrowska B, Sinkora J, Reháková Z, Sinkora M, Splíchal I, Tucková L, Avrameas S, Saalmüller A, Barot-Ciorbaru R, Tlaskalová-Hogenová H.

Immunology. 1996, 88: 611-617.

Hemolytic function of opsonizing proteins of earthworm's coelomic fluid.

Authors: Sinkora M, Bilej M, Tuckova L, Romanovsky A.

Cell Biol Int. 1993, 17: 935-939.